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Vicodin Online Overnight - Get Instant Relief from Pain Vicodin is a potent combination of hydrocodone, a semi-synthetic opioid, and acetaminophen, a popular over-the-counter pain reliever. When taken together, these ingredients work in tandem to provide unmatched pain management capabilities. The hydrocodone component binds to opioid receptors in the brain, dulling the transmission of pain signals, while the acetaminophen amplifies its effects to produce a synergistic analgesic effect.